Hydrochloric Acid → 6-Amino-1-cyclopropyl-5-nitroso-2,4(1H,3H)-pyrimidinedione
反応式
[NH2:1][C:2]1[N:7]([CH:8]2[CH2:10][CH2:9]2)[C:6](=[O:11])[NH:5][C:4](=[O:12])[CH:3]=1.Cl.[N:14]([O-])=[O:15].[Na+]>O>[NH2:1][C:2]1[N:7]([CH:8]2[CH2:10][CH2:9]2)[C:6](=[O:11])[NH:5][C:4](=[O:12])[C:3]=1[N:14]=[O:15]参加物
5
実験手順
31.7 g (0.19 mol) of 6-amino-1-cyclopropyl-2,4-(1H,3H)-pyrimidinedione (II) was suspended in 250 ml water. To this was added 45 ml of 5N HCl and 15 g of NaNO2 (0.22 mol) which was dissolved in water. The reaction mixture was stirred for 2 hours and after cooling, the red crystals were filtered off and washed with water. Yield 31.9 g (86%) (III) NMR.
後処理
- temperatureafter cooling
- filtrationthe red crystals were filtered off
- washwashed with water
出典と根拠
- ORDレコード
- ord-23f0ec4a203c41439a804afeacc0a235
- 出典データセット
- uspto-grants-1985_10
- 特許番号
- US04548818
反応ノート
読み込み中…