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Hydrochloric Acid → 6-Amino-1-cyclopentyl-5-nitroso-2,4(1h,3h)-pyrimidinedione
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | 6-Amino-1-cyclopentyl-1,3-dihydropyrimidine-2,4-dione | HCID 21958549 | — |
| 反応物 | Sodium Nitrite | HCID 23668193 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 6-Amino-1-cyclopentyl-5-nitroso-2,4(1h,3h)-pyrimidinedione | HCID 21958506 | — |
反応手順
12.4 g (0.064 mol) of 6-amino-1-cyclopentyl-2,4-(1H,3H)-pyrimidinedione (XIV) was suspended in 200 ml water. To this was added 14 ml of 5N HCl and 4.8 g of NaNO2 (0.07 mol) which was dissolved in water. The reaction mixture was stirred for 1 hour and washed with water. Yield 12.9 g (90%) (XV) NMR.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04548818 |
| 出典データセット | uspto-grants-1985_10 |
| ORD ID | ord-8555b679fcc141958fbd7bc427692110 |
| 出典メモ | uspto-grants-1985_10 |