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Hydrochloric Acid → 3-Chloro-5-nitro-2(1H)-pyridinone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | 5-Nitropyridin-2-ol | HCID 79453 | — |
| 反応物 | Potassium Chlorate | HCID 6426889 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 3-Chloro-5-nitro-2(1H)-pyridinone | HCID 336289 | — |
反応手順
5-Nitro-2-pyridone (Aldrich Chemical Company) (100 g, 0.71 mol) was added to 1 liter conc. HCl at room temperature, followed by the dropwise addition of a solution of potassium chlorate (87.5 g, 0.71 mol) in 1.2 liter water. A solid material formed during the addition. The mixture was stirred overnight, filtered, and the collected material recrystallized from 50 percent aqueous ethanol. The yield was 77.2 g, 62 percent, m.p. 196°-198° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04548888 |
| 出典データセット | uspto-grants-1985_10 |
| ORD ID | ord-14f5395969a04bf0b5ae561b9969b5b2 |
| 出典メモ | uspto-grants-1985_10 |