Dimethylformamide → 1-(2,6-Dimethoxybenzoyl)-3-(6-Cyclohexylsulfonyl-3-Pyridinyl)Urea
反応式
[CH:1]1([S:7]([C:10]2[CH:15]=[CH:14][C:13]([NH2:16])=[CH:12][N:11]=2)(=[O:9])=[O:8])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH3:17][O:18][C:19]1[CH:29]=[CH:28][CH:27]=[C:26]([O:30][CH3:31])[C:20]=1[C:21]([N:23]=[C:24]=[O:25])=[O:22].CN(C=O)C>O>[CH3:31][O:30][C:26]1[CH:27]=[CH:28][CH:29]=[C:19]([O:18][CH3:17])[C:20]=1[C:21]([NH:23][C:24]([NH:16][C:13]1[CH:12]=[N:11][C:10]([S:7]([CH:1]2[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]2)(=[O:8])=[O:9])=[CH:15][CH:14]=1)=[O:25])=[O:22]参加物
5
実験手順
2-Cyclohexylsulfonyl-5-aminopyridine (1.0 gram) and 2,6-dimethoxybenzoyl isocyanate (0.9 gram) were mixed in 50 ml. of DMF and stirred at room temperature overnight (about 18 hours). The reaction mixture was then poured into water and filtered to separate the product. It was crystallized from ethyl acetate-hexanes, yield 0.5 gram, m.p., 123°-125° C.