化工社化工社 化学情報印刷レポート · 研究参考用
Nitromethane → Benzenepropanoic acid, b-(nitromethyl)-, methyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Nitromethane | HCID 6375 | — |
| 反応物 | 2-Propenoic acid, 3-phenyl-, methyl ester | HCID 7644 | — |
| 反応物 | 1,1,3,3-Tetramethylguanidine | HCID 66460 | — |
| 溶媒 | Hydrochloric Acid | HCID 313 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 生成物 | Benzenepropanoic acid, b-(nitromethyl)-, methyl ester | HCID 10537045 | — |
反応手順
A mixture of 300 g of cinnamic acid methyl ester, 500 g of nitromethane and 39 g of tetramethylguanidine is allowed to stir at room temperature for 72 hours. The solution is diluted with diethyl ether and aqueous hydrochloric acid solution (1 N, 1 liter) is added. The organic layer is separated dried over anhydrous magnesium sulfate, and evaporated to give 4-nitro-3-phenylbutanoic acid methyl ester.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04548947 |
| 出典データセット | uspto-grants-1985_10 |
| ORD ID | ord-9a036c4be5b54a1fb43c03258d5a8ee8 |
| 出典メモ | uspto-grants-1985_10 |