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Nitromethane → Methyl 3-(4-chlorophenyl)-4-nitrobutanoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Nitromethane | HCID 6375 | — |
| 反応物 | 1,1,3,3-Tetramethylguanidine | HCID 66460 | — |
| 反応物 | Methyl 3-(4-chlorophenyl)-2-propenoate | HCID 98955 | — |
| 溶媒 | Hydrochloric Acid | HCID 313 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 生成物 | Methyl 3-(4-chlorophenyl)-4-nitrobutanoate | HCID 14931333 | — |
反応手順
A mixture of 290 g of p-chlorocinnamic acid, methyl ester, 500 g of nitromethane and 39 g of tetramethylguanidine is allowed to stir for 72 hours. The solution is diluted with ethyl ether and aqueous hydrochloric acid solution (1 N, 1 liter) is added. The organic layer is separated, dried over anhydrous magnesium sulfate, and evaporated to give 4-nitro-3-(4-chlorophenyl)butanoic acid methyl ester.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04548947 |
| 出典データセット | uspto-grants-1985_10 |
| ORD ID | ord-e8769266aa604824bfe4c0763b4a3ee2 |
| 出典メモ | uspto-grants-1985_10 |