Nitromethane → 4-Nitro-3-(3,4-dichlorophenyl)butanoic acid methyl ester
反応式
[CH3:1][O:2][C:3](=[O:14])[CH:4]=[CH:5][C:6]1[CH:11]=[CH:10][C:9]([Cl:12])=[C:8]([Cl:13])[CH:7]=1.[N+:15]([CH3:18])([O-:17])=[O:16].CN(C)C(=N)N(C)C>C(OCC)C.Cl>[CH3:1][O:2][C:3](=[O:14])[CH2:4][CH:5]([C:6]1[CH:11]=[CH:10][C:9]([Cl:12])=[C:8]([Cl:13])[CH:7]=1)[CH2:18][N+:15]([O-:17])=[O:16]参加物
6
実験手順
A mixture of 300 g of 3,4-dichlorocinnamic acid methyl ester, 400 g of nitromethane and 26 g of tetramethylguanidine is allowed to stir for 72 hours. The solution is diluted with ethyl ether and aqueous hydrochloric acid solution (1 N, 1 liter) is added. The organic layer is separated, dried over anhydrous magnesium sulfate, and evaporated to give 4-nitro-3-(3,4-dichlorophenyl)butanoic acid methyl ester.
後処理
- additionis added
- customThe organic layer is separated
- dry with materialdried over anhydrous magnesium sulfate
- customevaporated
出典と根拠
- ORDレコード
- ord-a5462e0316cc4d8eaf0de03e347fea08
- 出典データセット
- uspto-grants-1985_10
- 特許番号
- US04548947
反応ノート
読み込み中…