Methyl Acrylate → 6-bromo-3,4-dihydro-2H-1-benzopyran-4-one
反応式
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][CH:3]=1.[C:9](OC)(=[O:12])[CH:10]=[CH2:11].BrC1C=CC(OC(C)C(O)=O)=CC=1>CO.S(=O)(=O)(O)O>[Br:1][C:2]1[CH:7]=[C:6]2[C:5](=[CH:4][CH:3]=1)[O:8][CH2:11][CH2:10][C:9]2=[O:12]参加物
6
実験手順
The title compound was prepared by the method of Canalini et al.2 by the reaction of 4-bromophenol (40 g, 0.23 mole) and methyl acrylate (100 ml) in the presence of Triton B (6 ml of a 40% solution in methanol); followed by dilute acid hydrolysis of the resulting ester and cyclisation of the (4-bromophenoxy)propionic acid in concentrated sulphuric acid. The product was recrystallised from petroleum ether (60°-80° C.) to give a white crystalline solid (6.80 g, 13%). M.p. 78°-80° C.
後処理
- additionby dilute
- customThe product was recrystallised from petroleum ether (60°-80° C.)
出典と根拠
- ORDレコード
- ord-ae529965070f41b6a10a3d9d6568a3a4
- 出典データセット
- uspto-grants-1985_10
- 特許番号
- US04548948
反応ノート
読み込み中…