Piperidine → 1-[2-(4-Methoxyphenylamino)benzoyl]piperidine
反応式
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([N:9]2C(=O)[O:14][C:12](=O)[C:11]3=[CH:17][CH:18]=[CH:19][CH:20]=[C:10]23)=[CH:5][CH:4]=1.[NH:21]1[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]1>CN(C)C=O>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([NH:9][C:10]2[CH:20]=[CH:19][CH:18]=[CH:17][C:11]=2[C:12]([N:21]2[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]2)=[O:14])=[CH:7][CH:8]=1参加物
4
実験手順
A mixture of 15 g (0.052 mole) of N-(4-methoxyphenyl)isatoic anhydride and 10 ml (0.11 mole) of piperidine in 50 ml of dimethylformamide was stirred at room temperature for two hours. The reaction mixture was concentrated in vacuo and the residue recrystallized from 75 ml of isopropyl alcohol to give 13.8 g of 1-[2-(4-methoxyphenylamino)benzoyl]piperidine, colorless powder, m.p. 106°-108° C.