関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 3-Hydroxybenzaldehyde | HCID 101 | — |
| 反応物 | Ammonia | HCID 222 | — |
| 反応物 | Formic Acid | HCID 284 | — |
| 反応物 | 3-Methylpiperidine | HCID 79081 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 3-[(3-Methylpiperidin-1-yl)methyl]phenol | HCID 13364666 | — |
反応手順
24.4 g (0.2 mol) of 3-hydroxybenzaldehyde are mixed with 40 ml (about 0.4 mol) of 3-methylpiperidine and 20 ml (about 0.52 mol) of 100% formic acid with cooling and then stirred for 2 hours at 120° C. When the reaction mixture has cooled to room temperature, it is poured into water and rendered alkaline with ammonia, and the precipitated solid is filtered off and recrystallised from ethanol.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US04727081 |
|---|
| 出典データセット | uspto-grants-1988_02 |
|---|
| ORD ID | ord-e9c53b21b5524c4296badbb52530d5b3 |
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| 出典メモ | uspto-grants-1988_02 |
|---|
