Phthalic Acid → 2-(1H-Indazol-3-yl)-1H-isoindole-1,3(2H)-dione

HRID 464817ノート

反応式

HRID 464817 の反応式
[NH2:1][C:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[NH:4][N:3]=1.[C:11](O)(=[O:21])[C:12]1[C:13](=[CH:17][CH:18]=[CH:19][CH:20]=1)[C:14](O)=[O:15].C(OCC)C>O>[C:11]1(=[O:21])[N:1]([C:2]2[C:10]3[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=3)[NH:4][N:3]=2)[C:14](=[O:15])[C:13]2=[CH:17][CH:18]=[CH:19][CH:20]=[C:12]12

参加物

5

反応物 3

HCID 1017Phthalic AcidHCID 3283Diethyl EtherHCID 133991H-indazol-3-amine

生成物 1

HCID 27558572-(1H-Indazol-3-yl)-1H-isoindole-1,3(2H)-dione収率 87%

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
120 °C

実験手順

5.0 g of the same 3-aminoindazole as Example 1 and 6.68 g of phthalic acid were added to 50 ml of dixoane, and the mixture was stirred for 5 hours at 120° C. The mixture was condensed under reduced pressure, 30 ml of diethyl ether was added and the mixture was stirred under cooling with ice and water for 30 minutes to separate crystals. The crystals were obtained by filtration and dried under reduced pressure to give 8.6 g of 3-phthalimidoindazole in a yield of 87%.

後処理

  1. additionwas added
  2. stirringthe mixture was stirred
  3. customto separate crystals
  4. customThe crystals were obtained by filtration
  5. customdried under reduced pressure

出典と根拠

ORDレコード
ord-02efb5e9fcbc4826999ed255b3ec1c4c
出典データセット
uspto-grants-1985_10
特許番号
US04549023

反応ノート

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