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Formaldehyde → (E)-5-Dimethylamino-1-phenyl-pent-1-en-3-one; hydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Formaldehyde | HCID 712 | — |
| 反応物 | Dimethylamine, hydrochloride | HCID 10473 | — |
| 反応物 | Benzylideneacetone | HCID 637759 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | (E)-5-Dimethylamino-1-phenyl-pent-1-en-3-one; hydrochloride | HCID 145789 | — |
反応手順
trans-4-Phenyl-3-buten-2-one (14.6 g, 0.1 mole), dimethylamine hydrochloride (9.0 g, 0.1 mole) and paraformaldehyde (5.8 g, 0.2 mole) are heated at reflux in 150 ml of absolute ethanol for 3 hours. The reaction mixture is concentrated in vacuo, then washed with ether. Addition of ethyl acetate causes crystallization. The product is recrystallized from acetonitrile to yield 6.9 g, m.p. 150°-154° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04173649 |
| 出典データセット | uspto-grants-1979_11 |
| ORD ID | ord-f3e5da1636a14bf7a4e253b7767463fe |
| 出典メモ | uspto-grants-1979_11 |