Water → 2,3-Epoxypropyl 3-methylflavone-8-carboxylate

HRID 464981ノート

反応式

HRID 464981 の反応式
[CH3:1][C:2]1[C:11](=[O:12])[C:10]2[C:5](=[C:6]([C:13]([OH:15])=[O:14])[CH:7]=[CH:8][CH:9]=2)[O:4][C:3]=1[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1.[O:22]1[CH2:26][CH:23]1[CH2:24]O.C(N(CC)CC)C.O>C1C=CC=CC=1>[CH3:1][C:2]1[C:11](=[O:12])[C:10]2[C:5](=[C:6]([C:13]([O:15][CH2:24][CH:23]3[O:22][CH2:26]3)=[O:14])[CH:7]=[CH:8][CH:9]=2)[O:4][C:3]=1[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1

参加物

6

反応物 4

HCID 962WaterHCID 8471TriethylamineHCID 11164GlycidolHCID 770163-Methylflavone-8-carboxylic acid

生成物 1

HCID 102463862,3-Epoxypropyl 3-methylflavone-8-carboxylate収率 75.2%

試薬・触媒・溶媒 1

HCID 241Benzene溶媒

実験手順

21.3 g of 3-methylflavone-8-carboxylic acid were slowly added, over a period of 4 hours at 20° C., to a stirred solution of 5.55 g of 2,3-epoxy-1-propanol and 8.34 g of triethylamine in 165 ml of anhydrous benzene. The mixture was permitted to stand at 20°-25° C. for 20 hours, and then 60 ml of water were added. The entire reaction mass was stirred for 15 minutes and the layers were separated. The organic layer was washed and dried, the solvent was evaporated off and 18.95 g of 2,3-epoxypropyl 3-methylflavone-8-carboxylate, m.p. 103°-105° C., were obtained.

後処理

  1. customthe layers were separated
  2. washThe organic layer was washed
  3. customdried
  4. customthe solvent was evaporated off

出典と根拠

ORDレコード
ord-07777b7bc34747e9855f4006a88dbfee
出典データセット
uspto-grants-1985_10
特許番号
US04550115

反応ノート

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