Water → 2-(3-Hydroxy-1,2,3,4-tetrahydronaphthalenyl)-pyridine

HRID 46503ノート

反応式

HRID 46503 の反応式
[O:1]1[CH:11]2[CH:2]1[CH2:3][C:4]1[C:9]([CH2:10]2)=[CH:8][CH:7]=[CH:6][CH:5]=1.[N:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[Li].O>CCOCC>[OH:1][CH:11]1[CH2:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]([C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][N:12]=2)[CH2:2]1

参加物

5

反応物 3

HCID 962WaterHCID 108880512,3-Epoxy-1,2,3,4-tetrahydronaphthaleneHCID 178506720HCID 178506720、化合物

生成物 1

HCID 203873802-(3-Hydroxy-1,2,3,4-tetrahydronaphthalenyl)-pyridine

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

反応条件

温度
-20 °C

実験手順

A solution of 25 g of 2,3-epoxy-1,2,3,4-tetrahydronaphthalene in 250 ml ether is added to a solution of 2-pyridyl lithium (prepared from 2-bromopyridine and butyllithium) cooled to -20° C. After addition, the mixture is allowed to come to room temperature over several hours, then cooled again and treated with water. The separated, dried organics are taken to dryness, and the product purified by chromatography in neutral alumina.

後処理

  1. additionAfter addition
  2. waitto come to room temperature over several hours
  3. temperaturecooled again
  4. customthe product purified by chromatography in neutral alumina

出典と根拠

ORDレコード
ord-e020e1f78509438189a408ee230a55d1
出典データセット
uspto-grants-1979_11
特許番号
US04173640

反応ノート

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