Diethyl-piperidin-3-ylmethyl-amine → 5-[[3-[(Diethylamino)methyl]-1-piperidinyl]acetyl]-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one dihydrochloride dihydrate
反応式
[Cl:1][CH2:2][C:3]([N:5]1[C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=2[C:9](=[O:16])[NH:8][C:7]2[CH:17]=[CH:18][CH:19]=[CH:20][C:6]1=2)=[O:4].[CH2:21]([N:23]([CH2:26][CH:27]1[CH2:32][CH2:31][CH2:30][NH:29][CH2:28]1)[CH2:24][CH3:25])[CH3:22]>C(O)(C)C.C(OCC)(=O)C>[OH2:4].[OH2:4].[ClH:1].[ClH:1].[CH2:21]([N:23]([CH2:26][CH:27]1[CH2:32][CH2:31][CH2:30][N:29]([CH2:2][C:3]([N:5]2[C:11]3[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=3[C:9](=[O:16])[NH:8][C:7]3[CH:17]=[CH:18][CH:19]=[CH:20][C:6]2=3)=[O:4])[CH2:28]1)[CH2:24][CH3:25])[CH3:22]参加物
4
反応物 2
生成物 1
試薬・触媒・溶媒 1
実験手順
The title compound is prepared analogously to Example 35 from 5-(chloroacetyl)-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one and 3-[(diethylamino)methyl]piperidine to give colorless crystals, mp. 140° C. (isopropanol/ethyl acetate).