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2,2,2-Trifluoroethylhydrazine → 4,5-dihydro-2-[2-(2,2,2-trifluoroethyl)hydrazino]-1H-imidazole, hydroiodide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2,2,2-Trifluoroethylhydrazine | HCID 78740 | — |
| 反応物 | 1H-Imidazole, 4,5-dihydro-2-(methylthio)-, hydriodide (1:1) | HCID 12221228 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 4,5-dihydro-2-[2-(2,2,2-trifluoroethyl)hydrazino]-1H-imidazole, hydroiodide | HCID 131714398 | — |
反応手順
To a solution of 12.2 g of 2-methylthioimidazoline, hydroiodide in 30 ml of ethanol was slowly added 12.6 g of 2,2,2-trifluoroethyl hydrazine, dropwise over 30 minutes. This mixture was refluxed overnight, then evaporated to an oil which crystallized on standing, giving 4,5-dihydro-2-[2-(2,2,2-trifluoroethyl)hydrazino]-1H-imidazole, hydroiodide, a one gram portion of which was reacted as described in Example 33, giving 1.0 g of the desired product, mp>290° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04550169 |
| 出典データセット | uspto-grants-1985_10 |
| ORD ID | ord-67b5c6a5a2cd471481aa92f5eaf23e6f |
| 出典メモ | uspto-grants-1985_10 |