Ethyl orthoformate → 7-(2-Pyridinyl)-1,2,4-triazolo[4,3-a]pyridine

HRID 465122ノート

反応式

HRID 465122 の反応式
[NH:1]([C:3]1[CH:8]=[C:7]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][N:10]=2)[CH:6]=[CH:5][N:4]=1)[NH2:2].[CH:15](OCC)(OCC)OCC>>[N:10]1[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=1[C:7]1[CH:6]=[CH:5][N:4]2[CH:15]=[N:2][N:1]=[C:3]2[CH:8]=1

参加物

3

反応物 2

HCID 31214Ethyl orthoformateHCID 135337172'-Hydrazino-2,4'-bipyridine

生成物 1

HCID 135337087-(2-Pyridinyl)-1,2,4-triazolo[4,3-a]pyridine

実験手順

A mixture of 2.0 g of 2'-hydrazino-2,4'-bipyridine and 50 ml of triethyl orthoformate was heated on a steam bath for 18 hours then chilled and filtered. The crystals were dissolved in methylene chloride, treated with activated carbon, filtered and the filtrate concentrated. Chilling and filtration gave 1.5 g of the desired product as cream colored crystals, mp 144-°145° C.

後処理

  1. temperaturewas heated on a steam bath for 18 hours
  2. temperaturethen chilled
  3. filtrationfiltered
  4. dissolutionThe crystals were dissolved in methylene chloride
  5. additiontreated with activated carbon
  6. filtrationfiltered
  7. concentrationthe filtrate concentrated
  8. temperatureChilling
  9. filtrationfiltration

出典と根拠

ORDレコード
ord-1ff8877b5ac34ea2b3950340a906c49d
出典データセット
uspto-grants-1985_10
特許番号
US04550166

反応ノート

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