化工社化工社 化学情報印刷レポート · 研究参考用
Triethylamine → Methyl 4-(3-hydroxyanilino)-4-oxobutanoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 3-Aminophenol | HCID 11568 | — |
| 反応物 | Butanoic acid, 4-chloro-4-oxo-, methyl ester | HCID 73888 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | Methyl 4-(3-hydroxyanilino)-4-oxobutanoate | HCID 13491817 | 88% |
反応手順
To an ice cold solution of 3-aminophenol (21.8 g, 0.2 mol) and triethylamine (21.3 g, 0.2 mol) in tetrahydrofuran (250 ml) is added a solution of 3-carbomethoxypropanoyl chloride (30.1 g, 0.2 mol) in tetrahydrofuran. The reaction is allowed to warm to room temperature and is filtered through a pad of Celite and silica gel. The solvent is removed in vacuo to give a solid. Recrystallization from ethyl acetate gives 39.3 g (88% yield) of product, m.p. 144.5°-146° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04550172 |
| 出典データセット | uspto-grants-1985_10 |
| ORD ID | ord-5584d776a8db4dcc8b6c5a6e6f45bfb2 |
| 出典メモ | uspto-grants-1985_10 |