化工社化工社 化学情報印刷レポート · 研究参考用
Sodium Carbonate → 1-{3-[(1,3-Benzothiazol-2-yl)methoxy]phenyl}pyrrolidine-2,5-dione
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium Carbonate | HCID 10340 | — |
| 反応物 | Cesium carbonate | HCID 10796 | — |
| 反応物 | 2-(Chloromethyl)benzothiazole | HCID 304978 | — |
| 反応物 | Methyl 4-(3-hydroxyanilino)-4-oxobutanoate | HCID 13491817 | — |
| 触媒 | Potassium Iodide | HCID 4875 | — |
| 溶媒 | Acetone | HCID 180 | — |
| 生成物 | 1-{3-[(1,3-Benzothiazol-2-yl)methoxy]phenyl}pyrrolidine-2,5-dione | HCID 13491818 | 60.9% |
反応手順
A mixture of 4-[[3-(hydroxy)phenyl]amino]-4-oxobutanoic acid, methyl ester (1.45 g, 6.5 mmol), 2-chloromethylbenzothiazole (1.20 g, 6.5 mmol), cesium carbonate (1.0 g), sodium carbonate (0.7 g), potassium iodide (5 mg) and acetone (60 ml) is heated at reflux for 2 hours. The reaction is filtered through a pad of Celite and silica gel and the solvent is removed in vacuo. Recrystallization from acetone gives 1.34 g (56% yield) of product, m.p. 175°-176° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04550172 |
| 出典データセット | uspto-grants-1985_10 |
| ORD ID | ord-344a4a7e534e487d9fdbceb644f876a5 |
| 出典メモ | uspto-grants-1985_10 |