p-Toluenesulfonic acid monohydrate → HCID 18599866、化合物

HRID 465193ノート

反応式

HRID 465193 の反応式
[N:1]([C@H:4]1[NH:7][C:6](=[O:8])[C@H:5]1[NH:9]C(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)=[N+:2]=[N-:3].O.C1(C)C=CC(S(O)(=O)=O)=CC=1>CC(C)=O>[NH2:9][C@H:5]1[C@@H:4]([N:1]=[N+:2]=[N-:3])[NH:7][C:6]1=[O:8]

参加物

4

反応物 2

HCID 521998p-Toluenesulfonic acid monohydrateHCID 53771027HCID 53771027、化合物

生成物 1

HCID 18599866HCID 18599866、化合物

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

To a solution of 0.45 g of (3S,4R)-4-azido-3-tritylamino-2-oxoazetidine in 4 ml of acetone is added under ice-cooling 0.255 g of p-toluenesulfonic acid monohydrate, and the mixture is stirred for one hour at room temperature. The solvent is distilled off, and the resulting crystals are washed with ether. The crystals are collected by filtration to give 0.33 g of tosyl salt of (3S,4R)-3-amino-4-azido-2-oxoazetidine.

後処理

  1. distillationThe solvent is distilled off
  2. washthe resulting crystals are washed with ether
  3. filtrationThe crystals are collected by filtration

出典と根拠

ORDレコード
ord-6c6365de36684774b32baca07e082103
出典データセット
uspto-grants-1985_10
特許番号
US04550105

反応ノート

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