Triethylamine → 2-(3-Phenoxybenzoyl)-3-dimethylaminoacrylonitrile

HRID 465274

反応式

HRID 465274 の反応式
[O:1]([C:8]1[CH:9]=[C:10]([CH:14]=[CH:15][CH:16]=1)[C:11](Cl)=[O:12])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:17][N:18]([CH3:23])[CH:19]=[CH:20][C:21]#[N:22].C(N(CC)CC)C>O1CCOCC1>[O:1]([C:8]1[CH:9]=[C:10]([CH:14]=[CH:15][CH:16]=1)[C:11]([C:20](=[CH:19][N:18]([CH3:23])[CH3:17])[C:21]#[N:22])=[O:12])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

5

反応物 3

HCID 8471TriethylamineHCID 974973-(Dimethylamino)prop-2-enenitrileHCID 27603413-Phenoxybenzoyl chloride

生成物 1

HCID 540996322-(3-Phenoxybenzoyl)-3-dimethylaminoacrylonitrile収率 36.2%

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

A mixture of 3-phenoxybenzoyl chloride (6.9 g), 3-dimethylaminoacrylonitrile (2 g) and triethylamine (4 g) in dry dioxan (50 ml) was refluxed for 6 hours under a nitrogen atmosphere. After standing at room temperature overnight, the dioxan was evaporated in vacuo and dichloromethane added to the residue. The extracts were washed with water, 2N NaOH, brine and finally dried over MgSO4. After filtration and evaporation of the dichloromethane, the residue was purified on a silica gel column using 5% methanol-dichloromethane as eluant to give the title compound (2.2 g, 36%) as a white solid of m.p. 80°-82° C. (identical to that described in Example 46).

後処理

  1. temperaturewas refluxed for 6 hours under a nitrogen atmosphere
  2. customthe dioxan was evaporated in vacuo and dichloromethane
  3. additionadded to the residue
  4. washThe extracts were washed with water, 2N NaOH, brine
  5. dry with materialfinally dried over MgSO4
  6. filtrationAfter filtration and evaporation of the dichloromethane
  7. customthe residue was purified on a silica gel column

出典と根拠

ORDレコード
ord-30ba1b7a3a6a4330b33d69566dcace07
出典データセット
uspto-grants-1992_10
特許番号
US05152825

関連ノート

読み込み中…