Piperidine → O,S-Dimethyl 1-Piperidinylcarbonylphosphoramidothioate

HRID 465298ノート

反応式

HRID 465298 の反応式
[P:1](=[O:9])([N:6]=[C:7]=[O:8])([S:4][CH3:5])[O:2][CH3:3].[NH:10]1[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]1>CCOCC>[N:10]1([C:7]([NH:6][P:1](=[O:9])([S:4][CH3:5])[O:2][CH3:3])=[O:8])[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]1

参加物

4

反応物 2

HCID 8082PiperidineHCID 14879948O,S-dimethyl phosphoroisocyanatidothioate

生成物 1

HCID 19873990O,S-Dimethyl 1-Piperidinylcarbonylphosphoramidothioate

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

A solution of 6.0 grams (g) of O,S-dimethyl phosphoroisocyanatidothioate in 100 milliliters (ml) of ether was cooled to 0° C. and to this was added dropwise with stirring 3.1 g of piperidine. A precipitate began to form almost immediately and after one hour this precipitate was collected by filtration and extracted with ether. It was then recrystallized from toluene-hexane to obtain the title compound as white crystals melting at 96° C.

後処理

  1. additionto this was added dropwise
  2. customto form almost immediately and after one hour this precipitate
  3. filtrationwas collected by filtration
  4. extractionextracted with ether
  5. customIt was then recrystallized from toluene-hexane

出典と根拠

ORDレコード
ord-452fd9f5f47346f1936dbfed9e5ca2b3
出典データセット
uspto-grants-1992_10
特許番号
US05153184

反応ノート

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