Hydrochloric Acid → 7-(3-Pyrrolidinyloxy)-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid hydrochloride

HRID 465374ノート

反応式

HRID 465374 の反応式
C(OC([N:8]1[CH2:12][CH2:11][CH:10]([O:13][C:14]2[CH:23]=[C:22]3[C:17]([C:18](=[O:32])[C:19]([C:27]([O:29]CC)=[O:28])=[CH:20][N:21]3[CH:24]3[CH2:26][CH2:25]3)=[CH:16][C:15]=2[F:33])[CH2:9]1)=O)(C)(C)C.[ClH:34]>C(O)(=O)C>[ClH:34].[NH:8]1[CH2:12][CH2:11][CH:10]([O:13][C:14]2[CH:23]=[C:22]3[C:17]([C:18](=[O:32])[C:19]([C:27]([OH:29])=[O:28])=[CH:20][N:21]3[CH:24]3[CH2:26][CH2:25]3)=[CH:16][C:15]=2[F:33])[CH2:9]1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 15021537Ethyl 7-(1-t-butoxycarbonyl-3-pyrrolidinyloxy)-1-cyclopropyl-6-fluoro1,4-dihydro-4-oxoquinoline-3-carboxylate

生成物 1

HCID 679157567-(3-Pyrrolidinyloxy)-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid hydrochloride

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

Ethyl 7-(1-t-butoxycarbonyl-3-pyrrolidinyloxy)-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3carboxylate (210 mg) was dissolved in a mixture consisting of 0.7 ml of concentrated hydrochloric acid and 2.8 ml of acetic acid. The resulting solution was heated under reflux for 3 hours. The reaction mixture was concentrated to dryness under reduced pressure. The residue was recrystallized from ethanol, whereby 60 mg of the title compound was obtained as crystals.

後処理

  1. temperatureThe resulting solution was heated
  2. temperatureunder reflux for 3 hours
  3. concentrationThe reaction mixture was concentrated to dryness under reduced pressure
  4. customThe residue was recrystallized from ethanol

出典と根拠

ORDレコード
ord-7677fad717f24058a18f08e23d6b4e87
出典データセット
uspto-grants-1992_10
特許番号
US05153203

反応ノート

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