Hydrochloric Acid → 7-(3-Pyrrolidinyloxy)-1-cyclopropyl-6-fluoro-8-methoxy-1,4--dihydro-4-oxoquinoline-3-carboxylic acid hydrochloride
反応式
C(OC([N:8]1[CH2:12][CH2:11][CH:10]([O:13][C:14]2[C:23]([O:24][CH3:25])=[C:22]3[C:17]([C:18](=[O:32])[C:19]([C:29]([OH:31])=[O:30])=[CH:20][N:21]3[CH:26]3[CH2:28][CH2:27]3)=[CH:16][C:15]=2[F:33])[CH2:9]1)=O)(C)(C)C.[ClH:34]>C(O)(=O)C>[ClH:34].[NH:8]1[CH2:12][CH2:11][CH:10]([O:13][C:14]2[C:23]([O:24][CH3:25])=[C:22]3[C:17]([C:18](=[O:32])[C:19]([C:29]([OH:31])=[O:30])=[CH:20][N:21]3[CH:26]3[CH2:28][CH2:27]3)=[CH:16][C:15]=2[F:33])[CH2:9]1参加物
4
反応物 2
生成物 1
試薬・触媒・溶媒 1
実験手順
The whole amount of the 7-(1-t-butoxycarbonyl-3-pyrrolidinyloxy)-1-cyclopropyl-6-fluoro-8-methoxy-1,4-dihydro-4-oxoquinoline-3-carboxylic acid obtained above was dissolved in a mixture which consisted of 1.25 ml of concentrated hydrochloric acid and 5 ml of acetic acid. The resultant solution was heated under reflux for 1 hour. The reaction mixture was concentrated to dryness under reduced pressure. The residue thus obtained was recrystallized from ethanol, whereby 120 mg of the title compound was obtained as colorless needle crystals.