Potassium Iodide → 3,4-dihydro-5-(4-acetonyloxyphenyl) 6-methyl-2(1H)-pyridinone

HRID 465448ノート

反応式

HRID 465448 の反応式
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH2:9][CH2:10][C:11](=[O:15])[NH:12][C:13]=2[CH3:14])=[CH:4][CH:3]=1.Cl[CH2:17][C:18](=[O:20])[CH3:19].C(=O)([O-])[O-].[K+].[K+].[I-].[K+]>CC(C)=O>[CH2:17]([O:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH2:9][CH2:10][C:11](=[O:15])[NH:12][C:13]=2[CH3:14])=[CH:6][CH:7]=1)[C:18]([CH3:19])=[O:20]

参加物

6

反応物 4

HCID 4875Potassium IodideHCID 6571ChloroacetoneHCID 11430Potassium CarbonateHCID 132689765-(4-Hydroxyphenyl)-6-methyl-3,4-dihydropyridin-2(1H)-one

生成物 1

HCID 198745663,4-dihydro-5-(4-acetonyloxyphenyl) 6-methyl-2(1H)-pyridinone

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

A mixture of 3,4-dihydro-5-(4-hydroxyphenyl)-6-methyl-2(1H)-pyridinone (0.94 g), chloroacetone (0.43 g) and potassium carbonate (0.64 g), with a catalytic amount of potassium iodide, was stirred and heated under reflux in acetone (80 ml) for 16 hr. The solvent was evaporated and the residue partitioned between water and ethyl acetate. The organic layer was dried (MgSO4) and evaporated to give 3,4-dihydro-5-(4-acetonyloxyphenyl)-6-methyl-2(1H)-pyridinone as a solid.

後処理

  1. temperatureheated
  2. customThe solvent was evaporated
  3. customthe residue partitioned between water and ethyl acetate
  4. dry with materialThe organic layer was dried (MgSO4)
  5. customevaporated

出典と根拠

ORDレコード
ord-8e9de204cc9f4536ae735588dc99832d
出典データセット
uspto-grants-1992_10
特許番号
US05153210

反応ノート

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