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Bromine → 2-Bromo-1-(3,4-difluorophenyl)ethan-1-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Bromine | HCID 24408 | — |
| 反応物 | 2-Bromo-1-(2,4-dichlorophenyl)ethan-1-one | HCID 75828 | — |
| 反応物 | 1-(3,4-Difluorophenyl)ethan-1-one | HCID 123052 | — |
| 反応物 | 2-Bromo-1-(2,5-difluorophenyl)ethanone | HCID 2778264 | — |
| 反応物 | 2-Bromo-1-(3,4-diethoxyphenyl)ethan-1-one | HCID 3492104 | — |
| 反応物 | 2-Bromo-1-(3,4-dimethylphenyl)ethan-1-one | HCID 3703113 | — |
| 反応物 | 2-Bromo-1-(4-(propan-2-yl)phenyl)ethan-1-one | HCID 14042756 | — |
| 反応物 | 2-Bromo-1-(4-(propan-2-yloxy)phenyl)ethan-1-one | HCID 15453912 | — |
| 反応物 | m-Isobutylphenacyl bromide | HCID 20387511 | — |
| 反応物 | 2-Bromo-1-(3-ethoxyphenyl)ethanone | HCID 22641006 | — |
| 反応物 | 2-Bromo-1-(2-ethylphenyl)ethan-1-one | HCID 23442601 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 溶媒 | Chloroform | HCID 6212 | — |
| 生成物 | 2-Bromo-1-(3,4-difluorophenyl)ethan-1-one | HCID 2737032 | — |
反応手順
To a solution of 10.1 g. (0.065 mole) of 3,4-difluoroacetophenone in 100 ml. of glacial acetic acid was added 3.4 ml. (0.065 mole) of bromine dropwise. When the addition was complete the solution was stirred for 0.5 hr. and then stripped to dryness under reduced pressure. The residue was dissolved in chloroform and washed with aqueous sodium bicarbonate. Evaporation of the organic phase provided 14.8 g. (97%) of colorless liquid product. Similarly prepared were 2,4-dichlorophenacyl bromide, o-ethylphenacyl bromide, p-isopropylphenacyl bromide, m-isobutylphenacyl bromide, 3,4-dimethylphenacyl bromide, m-ethoxyphenacyl bromide, p-isopropoxyphenacyl bromide, 3,4-diethoxyphenacyl bromide, and 2,5-difluorophenacyl bromide.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04173650 |
| 出典データセット | uspto-grants-1979_11 |
| ORD ID | ord-51ac15fa7aa84ece864078149c112857 |
| 出典メモ | uspto-grants-1979_11 |