4-Toluenesulfonyl chloride → 5-Chloro-5-methoxycarbonyl-3-thiapentanenitrile
反応式
[Cl:1][CH:2]([C:9]([O:11][CH3:12])=[O:10])[CH2:3][S:4][CH2:5][C:6]([NH2:8])=O.S(Cl)(C1C=CC(C)=CC=1)(=O)=O>O>[Cl:1][CH:2]([C:9]([O:11][CH3:12])=[O:10])[CH2:3][S:4][CH2:5][C:6]#[N:8]参加物
4
実験手順
To the mixture obtained from Example 4, tosyl chloride (39.34 g) was added in portions with vigorous stirring and heat was evolved. The mixture was stirred for 9.5 hours, stood overnight, then poured into water (500 ml), and extracted with dichloromethane. The combined extracts were washed with water (×2) and saturated brine, dried (magnesium sulphate) and evaporated to yield the title compound as a dark red oil (27.05 g).
後処理
- temperatureheat
- stirringThe mixture was stirred for 9.5 hours
- extractionextracted with dichloromethane
- washThe combined extracts were washed with water (×2) and saturated brine
- dry with materialdried (magnesium sulphate)
- customevaporated
出典と根拠
- ORDレコード
- ord-6956bbdfc3bf4f0c9a1352b595c6dead
- 出典データセット
- uspto-grants-1992_10
- 特許番号
- US05153330
反応ノート
読み込み中…