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N-bromobutanimide → Methyl 4'-bromomethylbiphenyl-3-carboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | N-bromobutanimide | HCID 67184 | — |
| 反応物 | Methyl 3-(4-methylphenyl)benzoate | HCID 1394187 | — |
| 触媒 | Azobisisobutyronitrile | HCID 6547 | — |
| 溶媒 | Carbon Tetrachloride | HCID 5943 | — |
| 生成物 | Methyl 4'-bromomethylbiphenyl-3-carboxylate | HCID 12019907 | 100.4% |
反応手順
A solution of 7.31 g of Methyl 4'-methylbiphenyl-3-carboxylate, 5.75 g of N-bromosuccinimide, 0.125 g of azo(bisisobutyronitrile), and 500 mL of carbon tetrachloride was refluxed for 3 hours. After cooling to room temperature the resulting suspension was filtered and then concentrated in vacuo to provide 9.90 g of crude methyl 4'-bromomethylbiphenyl-3-carboxylate which was used in a subsequent reaction without further purification; NMR (200 MHz, CDCl3): δ8.28 (s, 1H); 8.05 (d, 1H); 7.79 (d, 1H); 7.67-7.48 (m, 5H); 4.55 (s, 2H); 3.98 (s, 3H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05153197 |
| 出典データセット | uspto-grants-1992_10 |
| ORD ID | ord-fb9f0ef8dd064a8ea1b7c299cb90de20 |
| 出典メモ | uspto-grants-1992_10 |