1-Ethynyl-4-methoxybenzene → 4-Methoxy-4'-(1-propynyl)tolan

HRID 465891ノート

反応式

HRID 465891 の反応式
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]#[CH:10])=[CH:5][CH:4]=1.[C:11]([C:14]1[CH:19]=[CH:18][C:17](I)=[CH:16][CH:15]=1)#[C:12][CH3:13]>C(NCC)C.[Cu](I)I>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]#[C:10][C:17]2[CH:18]=[CH:19][C:14]([C:11]#[C:12][CH3:13])=[CH:15][CH:16]=2)=[CH:5][CH:4]=1

参加物

5

反応物 2

HCID 2510201-Ethynyl-4-methoxybenzeneHCID 121767134-(1-Propynyl)iodobenzene

生成物 1

HCID 598753514-Methoxy-4'-(1-propynyl)tolan

試薬・触媒・溶媒 2

HCID 83717Copper iodide触媒HCID 8021Diethylamine溶媒

実験手順

4-Methoxyphenyl acetylene (2.65 g, 0.02 mol) and 4-(1-propynyl)iodobenzene (5.0 g, 0.02 mol) were dissolved in diethylamine (20 ml), and then added copper iodide (0.06 g) and dichlorobistriphenylphosphinepalladium dichloride (0.21 g) were added. The resulting mixture was subjected to reaction and purification operations in the same manners as in Example 1, to obtain the objective 4-methoxy-4'-(1-propynyl)tolan (No. 297) (1.35 g).

後処理

  1. customThe resulting mixture was subjected to reaction and purification operations in the same manners as in Example 1

出典と根拠

ORDレコード
ord-24a7db5658fb4840aea215ec309a8e30
出典データセット
uspto-grants-1992_10
特許番号
US05154851

反応ノート

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