Water → 1-(2-Sulfanylethyl)pyrrolidine-2,5-dione

HRID 465896

反応式

HRID 465896 の反応式
O.[SH:2][CH2:3][CH2:4][NH:5][C:6](=[O:12])[CH2:7][CH2:8][C:9]([OH:11])=O>C1(C)C(C)=CC=CC=1>[SH:2][CH2:3][CH2:4][N:5]1[C:6](=[O:12])[CH2:7][CH2:8][C:9]1=[O:11]

参加物

4

反応物 2

HCID 962WaterHCID 224508284-Oxo-4-[(2-sulfanylethyl)amino]butanoic acid

生成物 1

HCID 220163571-(2-Sulfanylethyl)pyrrolidine-2,5-dione収率 100.2%

試薬・触媒・溶媒 1

HCID 7237O-Xylene溶媒

反応条件

温度
140 °C

実験手順

In a 100 cm3 reactor fitted with a water separator (Dean Stark) there is heated to a temperature of 140° C. a mixture, stirred under an inert atmosphere, of 20 g of N-(2-mercapto ethyl) succinamic acid in 50 cm3 of xylene. After about 5 hours of reaction, the theoretical amount of water (2 cm3) is removed. The xylene is then distilled under reduced pressure. The crude product is dried and 18 g of a pasty product are obtained which slowly crystallizes at ambient temperature, its characteristics being the same as those of the product prepared following the procedures in section (a) immediately above.

後処理

  1. customAfter about 5 hours of reaction
  2. customthe theoretical amount of water (2 cm3) is removed
  3. distillationThe xylene is then distilled under reduced pressure
  4. dry with materialThe crude product is dried

出典と根拠

ORDレコード
ord-8cd426b10d72487bb13780b129cd085d
出典データセット
uspto-grants-1992_10
特許番号
US05154918

関連ノート

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