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Floxuridine → 2'-Deoxy-5-fluoro-3'-(2-methylbenzyl)uridine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Floxuridine | HCID 5790 | — |
| 反応物 | o-Xylyl bromide | HCID 6992 | — |
| 反応物 | Potassium Hydroxide | HCID 14797 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | 2'-Deoxy-5-fluoro-3'-(2-methylbenzyl)uridine | HCID 54222499 | 20.4% |
反応手順
A 1.14 g quantity of potassium hydroxide was dissolved in a mixture of 33 ml of water and 16 ml of acetonitrile. To the solution were added 1.00 g of 2'-deoxy-5-fluorouridine and 1.50 g of 2-methylbenzyl bromide at room temperature with stirring. Then the same subsequent procedures as in Examples 4 and 5 were conducted, giving 0.29 g of the title compound in a yield of 20%.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05155113 |
| 出典データセット | uspto-grants-1992_10 |
| ORD ID | ord-9c3a716382d945cfa97befce52e22a42 |
| 出典メモ | uspto-grants-1992_10 |