化工社化工社 化学情報印刷レポート · 研究参考用
Floxuridine → 2'-deoxy-5-fluoro-3'-O-(1-naphthylmethyl)-uridine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Floxuridine | HCID 5790 | — |
| 反応物 | Potassium Hydroxide | HCID 14797 | — |
| 反応物 | 1-(Bromomethyl)naphthalene | HCID 137844 | — |
| 生成物 | 2'-deoxy-5-fluoro-3'-O-(1-naphthylmethyl)-uridine | HCID 14074406 | 18% |
反応手順
The general procedures of Reference Examples 4 and 5 were followed using 1.3 g of potassium hydroxide, 1.00 g of 2'-deoxy-5-fluorouridine and 2.7 g of 1-naphthylmethyl bromide, thereby producing 0.28 g of the title compound in a yield of 18%.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05155113 |
| 出典データセット | uspto-grants-1992_10 |
| ORD ID | ord-d6c8084ee8ec40b2a2eb6cbd64127813 |
| 出典メモ | uspto-grants-1992_10 |