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Water → 6-benzyloxy-2H-1-benzopyran-3-carboxaldehyde
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Benzyl Bromide | HCID 7498 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 6-Hydroxychromene-3-carboxaldehyde | HCID 4770815 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 6-benzyloxy-2H-1-benzopyran-3-carboxaldehyde | HCID 14971260 | — |
反応手順
A mixture of 6-hydroxy-2H-1-benzopyran-3-carboxaldehyde (25.0 g, 0.14 mol) and potassium carbonate (39.2 g, 0.28 mol) in 500 ml of DMF is treated with benzyl bromide (26.7 g, 0.16 mol). The mixture is stirred overnight at room temperature. Water is added and three extractions with dichloromethane are carried out. The extract is dried (MgSO4) and evaporated to dryness. The residue is crystallized from hot ethyl acetate to give 6-benzyloxy-2H-1-benzopyran-3-carboxaldehyde, m.p. 112°-114° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05155130 |
| 出典データセット | uspto-grants-1992_10 |
| ORD ID | ord-12f6cde40e39456691a1140d3910462e |
| 出典メモ | uspto-grants-1992_10 |