化工社化工社 化学情報印刷レポート · 研究参考用
Isobutyl chloroformate → Morphine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Isobutyl chloroformate | HCID 62365 | — |
| 反応物 | Sodium Bicarbonate | HCID 516892 | — |
| 反応物 | HCID 131710346 | HCID 131710346 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | Morphine | HCID 5288826 | — |
反応手順
O3 -Carboxymethyl morphine (3.43 g) and 1.31 ml isobutyl chloroformate were combined in 30 ml DMF at 0°. The resulting clear solution was then added to a stirring solution of 2.88 g BSA and 13 g NaHCO3 in 600 ml of water at 0°. Addition was carried out by means of a syringe with its tip below the solution surface. The solution was stirred in a cold room overnight.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04174384 |
| 出典データセット | uspto-grants-1979_11 |
| ORD ID | ord-e97ed492edc14387bce9f58b66b21d96 |
| 出典メモ | uspto-grants-1979_11 |