Hydrochloric Acid → (2R)-3-(4-cyanophenoxy)propane-1,2-diol
反応式
CC1(C)[O:6][C@@H:5]([CH2:7][O:8][C:9]2[CH:14]=[CH:13][C:12]([C:15]#[N:16])=[CH:11][CH:10]=2)[CH2:4][O:3]1.Cl>CO.O>[C:15]([C:12]1[CH:13]=[CH:14][C:9]([O:8][CH2:7][C@H:5]([OH:6])[CH2:4][OH:3])=[CH:10][CH:11]=1)#[N:16]参加物
5
実験手順
77 g of (4S)-2,2-dimethyl-4-(4-cyanophenoxy)methyl-1,3-dioxolane, was dissolved in methanol (200 ml) and water (75 ml). Concentrated hydrochloric acid (0.5 ml) was added and the mixture was kept at 50° C. overnight. It was evaporated at reduced pressure and recrystallized from water to yield 46 g of the title compound as white leaves, m.p. 63°-65° C.
後処理
- customIt was evaporated at reduced pressure
- customrecrystallized from water
出典と根拠
- ORDレコード
- ord-7edee3fdbde24096831ee3b4e44bbf59
- 出典データセット
- uspto-grants-1992_10
- 特許番号
- US05155133
反応ノート
読み込み中…