Potassium Carbonate → 2,6-Dimethyl-4-[(trimethylsilyl)methoxy]phenol

HRID 466304

反応式

HRID 466304 の反応式
[CH3:1][C:2]1[CH:8]=[C:7]([OH:9])[CH:6]=[C:5]([CH3:10])[C:3]=1[OH:4].C(=O)([O-])[O-].[K+].[K+].Cl[CH2:18][Si:19]([CH3:22])([CH3:21])[CH3:20]>CN(C)C=O>[CH3:1][C:2]1[CH:8]=[C:7]([O:9][CH2:18][Si:19]([CH3:22])([CH3:21])[CH3:20])[CH:6]=[C:5]([CH3:10])[C:3]=1[OH:4]

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 695602,6-DimethylhydroquinoneHCID 75361Silane, (chloromethyl)trimethyl-

生成物 1

HCID 158723362,6-Dimethyl-4-[(trimethylsilyl)methoxy]phenol

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

Mix 2,6-dimethylhydroquinone (1.4 g, 10 mmol), potassium carbonate (1.4 g, 10 mmol), chloromethyltrimethylsilane (1.9 g, 10 mmol) and dimethylformamide (50 mL). Stir at room temperature under inert atmosphere until the reaction is complete. Dilute the mixture with ice-water and extract with ethyl ether. Wash the ethereal layer with water, then brine and filter through fluorosil-Na2SO4. Evaporate to give the title compound and purify by silica gel chromatography.

後処理

  1. extractionextract with ethyl ether
  2. washWash the ethereal layer with water
  3. filtrationbrine and filter through fluorosil-Na2SO4
  4. customEvaporate

出典と根拠

ORDレコード
ord-d7ec962c672c4f6d98f8665793f47027
出典データセット
uspto-grants-1992_10
特許番号
US05155250

関連ノート

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