Hydrochloric Acid → HCID 54014406、化合物

反応式

[OH-].[K+].[CH3:3][Si:4]([CH3:24])([CH3:23])[C:5]1[CH:6]=[C:7](/[CH:11]=[CH:12]/[C:13]2[CH:22]=[CH:21][C:16]([C:17]([O:19]C)=[O:18])=[CH:15][CH:14]=2)[CH:8]=[CH:9][CH:10]=1.Cl>CCO>[CH3:24][Si:4]([CH3:3])([CH3:23])[C:5]1[CH:6]=[C:7]([CH:11]=[CH:12][C:13]2[CH:14]=[CH:15][C:16]([C:17]([OH:19])=[O:18])=[CH:21][CH:22]=2)[CH:8]=[CH:9][CH:10]=1

参加物

実験手順

A solution of 1.8 ml (3.6 mmol) of 2N-KOH was added to a solution of 143 mg (0.461 mmol) of trans-methyl 4-[(3-trimethylsilylphenyl)ethenyl]benzoate in 3 ml of EtOH. The mixture was stirred at room temperature. The reaction mixture was adjusted to acid pH with 2N hydrochloric acid, and then the aqueous solution was extracted with AcOEt. The extract was dried and evaporated to give 137 mg of the title compound as white crystals (yield 100%), which were recrystallized from a mixture of ethyl acetate, methylene chloride and n-hexane, and dried to give 116 mg of white crystals, m.p. 216°-218° C. (yield 85%).