関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Methanesulfonyl chloride | HCID 31297 | — |
| 反応物 | 1-(4-Amino-3-methylphenyl)ethanone | HCID 13355515 | — |
| 溶媒 | Pyridine | HCID 1049 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | N-(4-Acetyl-2-methylphenyl)methanesulfonamide | HCID 19873430 | — |
反応手順
4'-Amino-3'-methylacetophenone from Step VIII (3.0 g, 20 mmol) in 15 ml of dry pyridine at 5° C. is reacted with 3.0 g (26.2 mmol) of methanesulfonyl chloride in 5 ml of tetrahydrofuran. The reaction is stirred at 5° C. for 2 hrs, then at room temperature overnight. The reaction is diluted with ice-water. The solid is collected, washed with water, air dried and crystallized from methylene chloride-pet. ether to yield the title compound; m.p. 152°-153° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05155268 |
|---|
| 出典データセット | uspto-grants-1992_10 |
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| ORD ID | ord-0ac4085aa85945ca8f78d814c4565448 |
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| 出典メモ | uspto-grants-1992_10 |
|---|
