Ammonia → 2,6-Difluoro-4-methoxybenzamide

HRID 466490ノート

反応式

HRID 466490 の反応式
[F:1][C:2]1[CH:10]=[C:9]([O:11][CH3:12])[CH:8]=[C:7]([F:13])[C:3]=1[C:4](Cl)=[O:5].[NH3:14]>COCCOCCOC>[F:1][C:2]1[CH:10]=[C:9]([O:11][CH3:12])[CH:8]=[C:7]([F:13])[C:3]=1[C:4]([NH2:14])=[O:5]

参加物

4

反応物 2

HCID 222AmmoniaHCID 27787682,6-Difluoro-4-methoxybenzoyl chloride

生成物 1

HCID 27787702,6-Difluoro-4-methoxybenzamide

試薬・触媒・溶媒 1

HCID 8150Diglyme溶媒

実験手順

The crude acid chloride (25) was dissolved in dry diglyme (60 ml) and added dropwise at room temperature with gentle stirring to 35% ammonia (750 ml). The resulting colourless precipitate was filtered off and dried (CaCl2) in vacuo to give a colourless solid.

後処理

  1. additionadded dropwise at room temperature
  2. filtrationThe resulting colourless precipitate was filtered off
  3. dry with materialdried (CaCl2) in vacuo
  4. customto give a colourless solid

出典と根拠

ORDレコード
ord-44569574662a42a0b3a3d9eed2e3c01e
出典データセット
uspto-grants-1992_10
特許番号
US05156763

反応ノート

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