化工社化工社 化学情報印刷レポート · 研究参考用
Water → Tegafur
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Tegafur | HCID 5386 | — |
| 反応物 | Boron trifluoride etherate | HCID 8000 | — |
| 溶媒 | 1,4-Dioxane | HCID 31275 | — |
| 生成物 | 5-Fluorouracil | HCID 3385 | — |
| 生成物 | Tegafur | HCID 5386 | 93% |
反応手順
1.600 g crude addition product of water to 2,3-dihydrofuran (prepared as described in Example 1) was added under stirring to a mixture of borontrifluoride-etherate (0.710 g; 5.0 m.mole) and anhydrous dioxane (20 ml) followed by the addition of silylated-5-fluorouracil (2,740 g; 10.0 m.mole). The reaction mixture was stirred for 3 hours at room temperature after which it was worked up as described in Example 1. 0.200 g unreacted 5-fluorouracil and 1.580 g (93%) Ftorafur were isolated.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04174446 |
| 出典データセット | uspto-grants-1979_11 |
| ORD ID | ord-7db13f0669c74dfcbb795e8755d87758 |
| 出典メモ | uspto-grants-1979_11 |