関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | p-Toluenesulfonic acid | HCID 6101 | — |
| 反応物 | 1,1,1-Trimethoxybutane | HCID 123512 | — |
| 反応物 | 2-Chloro-4,5-diamino-6-methylpyrimidine | HCID 275295 | — |
| 溶媒 | 2-Methoxyethanol | HCID 8019 | — |
| 生成物 | 2-Chloro-6-methyl-8-propylpurine | HCID 19012212 | 47.1% |
反応手順
A mixture of 2-Chloro-4,5-diamino-6-methylpyrimidine (0.80 g, 5.04 mmol), trimethylorthobutyrate (1.2 ml, 7.6 mmol) and p-TsOH (0.08 g) in 2-methoxyethanol (24 ml) was heated in an oil bath at 140° C. for 24 hours. The product was isolated as described in Step 2 of Example 12 and purified by flash chromatography using EtOAc-hexane (1:1) to give the crystalline titled compound (0.5 g, 47%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05157026 |
|---|
| 出典データセット | uspto-grants-1992_10 |
|---|
| ORD ID | ord-889a2aec602c401a8cdf19bffb69e9b2 |
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| 出典メモ | uspto-grants-1992_10 |
|---|
