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Chloromethyl pivalate → Ticlopidine Hydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Chloromethyl pivalate | HCID 87885 | — |
| 反応物 | N-((2-chlorophenyl)methyl)thiophene-3-ethylamine | HCID 6454012 | — |
| 溶媒 | Dimethyl Sulfoxide | HCID 679 | — |
| 生成物 | Ticlopidine Hydrochloride | HCID 65335 | 51% |
反応手順
66.5 g (0.44 M) chloromethyl pivalate is reacted by heating, for 3 hours, with a solution of 103 g (0.4 M) N-(2-chloro-benzyl)-2-(2-thienyl)ethylamine in 300 ml dimethylsulfoxide, to give the title compound in a yield of 51%.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04174448 |
| 出典データセット | uspto-grants-1979_11 |
| ORD ID | ord-e1e3cd2e741d47f5826cb8f92d901749 |
| 出典メモ | uspto-grants-1979_11 |