Imidazole → 1,3-Dihydro-1-[4-(1H-imidazol-1-yl)-2-butynyl]-3-methyl-2H-imidazol-2-one
反応式
[NH:1]1[CH:5]=[CH:4][N:3]=[CH:2]1.Br[CH2:7][C:8]#[C:9][CH2:10][N:11]1[CH:15]=[CH:14][N:13]([CH3:16])[C:12]1=[O:17]>O1CCOCC1>[N:1]1([CH2:7][C:8]#[C:9][CH2:10][N:11]2[CH:15]=[CH:14][N:13]([CH3:16])[C:12]2=[O:17])[CH:5]=[CH:4][N:3]=[CH:2]1参加物
4
実験手順
Imidazole (3.87 g, 0.057 mol) was added to a stirred solution of 1-(4-bromo-2-butynyl)-1,3-dihydro-3-methyl-2H-imidazol-2-one (3.26 g, 0.014 mol) in dioxane (50 mL). After 18 hr the dioxane was evaporated and the residue was chromatographed on silica gel to give 2.4 g of product.
後処理
- customAfter 18 hr the dioxane was evaporated
- customthe residue was chromatographed on silica gel
出典と根拠
- ORDレコード
- ord-2c2443c4e5134c559ec7248209210d08
- 出典データセット
- uspto-grants-1992_10
- 特許番号
- US05157124
反応ノート
読み込み中…