関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Butylamine | HCID 8007 | — |
| 反応物 | Thiopheneethanamine | HCID 116521 | — |
| 反応物 | 1,2,3-Triazinane | HCID 16048634 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 4,5,6,7-Tetrahydrothieno(3,2-c)pyridinium chloride | HCID 10176342 | 65% |
反応手順
To 73 ml dimethylformamide heated at 45° C. in which are dissolved 0.45 mole gaseous hydrochloric acid, is added, over 25 minutes, a mixture of 17 g (0.2 M) s.hexahydrotriazine of n. n.butylamine/and 26 g 2-(2-thienyl)ethylamine. The temperature of the medium is maintained at 45° C. throughout the addition by means of a cold water bath. The desired product precipitates out at the end of the addition. Filtration gives 22.16 g 4,5,6,7-tetrahydrothieno[3,2-c]pyridine hydrochloride (Yield: 65%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US04174448 |
|---|
| 出典データセット | uspto-grants-1979_11 |
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| ORD ID | ord-65a73172a95d42a492af8ff8c50eb674 |
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| 出典メモ | uspto-grants-1979_11 |
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