Hydrochloric Acid → 2-Fluoro-4-(1,1,2,2-tetrafluoroethoxy)aniline
反応式
C([NH:4][C:5]1[CH:10]=[CH:9][C:8]([O:11][C:12]([F:17])([F:16])[CH:13]([F:15])[F:14])=[CH:7][C:6]=1[F:18])(=O)C.Cl.C(=O)([O-])O.[Na+]>>[F:18][C:6]1[CH:7]=[C:8]([O:11][C:12]([F:16])([F:17])[CH:13]([F:15])[F:14])[CH:9]=[CH:10][C:5]=1[NH2:4]参加物
4
実験手順
0.60 Gram of 4-acetylamino-3-fluoro-1-(1,1,2,2-tetrafluoroethoxy)benzene and 10 ml of a 20% aqueous hydrochloric acid were added to a reactor and stirred under reflux for 2 hours. After cooling the reaction solution, a 5% aqueous sodium hydrogencarbonate solution was added to make the solution weakly alkaline. The reaction solution was then extracted with two 100-ml portions of diethyl ether. The ether layers were combined, dried and concentrated to obtain a yellow oily product as a residue. This oily product was subjected to chromatography on silica gel to obtain 0.40 g of 2-fluoro-4-(1,1,2,2-tetrafluoroethoxy)aniline.