化工社化工社 化学情報印刷レポート · 研究参考用
Hydrogen Bromide → 1-Bromo-3-fluorobenzene
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrogen Bromide | HCID 260 | — |
| 反応物 | 2-Fluoroaniline | HCID 9584 | — |
| 反応物 | 2,4-Difluoroaniline | HCID 9709 | — |
| 反応物 | 4-Fluoroaniline | HCID 9731 | — |
| 反応物 | Bromine | HCID 24408 | — |
| 反応物 | 4-Bromo-2-fluoroaniline | HCID 123050 | — |
| 反応物 | 2-Bromo-4,6-Difluoroaniline | HCID 136285 | — |
| 反応物 | 2-Bromo-4-fluoroaniline | HCID 242873 | — |
| 反応物 | Phosphinic Acid | HCID 4124402 | — |
| 反応物 | Sodium Nitrite | HCID 23668193 | — |
| 生成物 | 1-Bromo-3-fluorobenzene | HCID 14082 | — |
| 生成物 | 1-Bromo-3,5-difluorobenzene | HCID 136313 | — |
反応手順
In a particularly preferred embodiment of the present invention, Br2 is mixed with a starting material selected from the group consisting of 2-fluoroaniline, 4-fluoroaniline, 2,4-difluoroaniline or a mixture thereof. The Br2 is reacted with the selected starting material to form a corresponding intermediate material selected from the group consisting of 2-bromo-4-fluoroaniline.HBr, 4-bromo-2-fluoroaniline.HBr, 2-bromo-4,6-difluoroaniline.HBr and mixtures thereof. The resulting intermediate material then is mixed with a deaminating agent comprising NaNO2 and H3PO2. The intermediate material then is deaminated, under deaminating conditions, so as to form the desired end product, 3-bromofluorobenzene or 1-bromo-3,5-difluorobenzene.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05157169 |
| 出典データセット | uspto-grants-1992_10 |
| ORD ID | ord-330c0560309d4a5d90b1cd6b20bc63a9 |
| 出典メモ | uspto-grants-1992_10 |