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Water → 5-Phenyl-2-trityltetrazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Trityl chloride | HCID 6456 | — |
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | HCID 178418369 | HCID 178418369 | — |
| 溶媒 | Acetone | HCID 180 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 5-Phenyl-2-trityltetrazole | HCID 3292959 | 100.7% |
反応手順
To a suspension of 5-phenyltetrazole (5 g; 34 mmole), stirring in 55 mL of acetone, was added 3.6 g of triethylamine (36 mmoles). The mixture was aged for 15 minutes after which triphenylmethylchloride (10.0 g; 36 mmoles) in 20 mL of THF was added; the temperature rose 8°-10° C. After stirring for 1 hour, 75 mL of H2O was added and the mixture stirred for 1 hour. After filtration, washing with water and drying in vacuo at 70° C., 13.3 g of 18a was obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05157040 |
| 出典データセット | uspto-grants-1992_10 |
| ORD ID | ord-47d3016f67464ec7b2cbdc3d2cc81882 |
| 出典メモ | uspto-grants-1992_10 |