Water → Oxirane, [3-(4-chlorophenyl)propyl]-
反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][CH2:10][CH:11]=[CH2:12])=[CH:4][CH:3]=1.C(OO)(=[O:15])C.C([O-])(=O)C.[Na+].O>ClCCl>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][CH2:10][CH:11]2[O:15][CH2:12]2)=[CH:4][CH:3]=1参加物
6
実験手順
To a solution of 5-(4-chlorophenyl)pent-1-ene (43.2 g) in dichloromethane (400 mL) was added dropwise with stirring a mixture of 40% peracetic acid (200 mL) and sodium acetate (6.5 g). The resulting mixture was heated under reflux for 2 hours, cooled, and stirred with water (400 mL). The dichloromethane layer was separated, washed with dilute aqueous potassium carbonate until neutral, water, and dried (MgSO4) and evaporated to give 46.7 g of 5-(4-chlorophenyl)-1,2-epoxypentane as a colorless oil.
後処理
- temperatureThe resulting mixture was heated
- temperatureunder reflux for 2 hours
- temperaturecooled
- customThe dichloromethane layer was separated
- washwashed with dilute aqueous potassium carbonate until neutral, water
- dry with materialdried (MgSO4)
- customevaporated
出典と根拠
- ORDレコード
- ord-fe1bcf22ef464c588e66cca42665a13c
- 出典データセット
- uspto-grants-1992_10
- 特許番号
- US05158949
反応ノート
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