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2-Amino-4-Nitrophenol → 2-(Chloromethyl)-5-nitro-1,3-benzoxazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Amino-4-Nitrophenol | HCID 3613389 | — |
| 反応物 | Ethyl 2-chloroethanecarboximidate hydrochloride | HCID 12470659 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 2-(Chloromethyl)-5-nitro-1,3-benzoxazole | HCID 2764189 | — |
反応手順
2-Amino-4-nitrophenol (10 g, 65 mmole) and ethyl chloroacetimidate hydrochloride (15.4 g, 97.5 mmole) were heated at reflux temperature in ethanol (100 ml) for 18 hours. The solvent was then removed by evaporation in vacuo and the residue recrystallised from ethanol to give the title compound, yield 9.0 g, m.p. 216°-217°.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05158964 |
| 出典データセット | uspto-grants-1992_10 |
| ORD ID | ord-0c7cdef324e84958856a1348304f2bf5 |
| 出典メモ | uspto-grants-1992_10 |