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Dimethylformamide → Rifampicin
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dimethylformamide | HCID 6228 | — |
| 反応物 | 1,3,5-Tris(1,1-dimethylethyl)hexahydro-1,3,5-triazine | HCID 66352 | — |
| 反応物 | 1-Amino-4-methylpiperazine | HCID 81349 | — |
| 反応物 | Rifamycin S | HCID 6436726 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 生成物 | Rifampicin | HCID 135398735 | — |
反応手順
15 g. Rifamycin S are dissolved in 50 ml. dimethylformamide and 5.5 g. 1,3,5-tri-(tert.-butyl)-hexahydro-1,3,5-triazine are added to the solution. The reaction mixture is then kept at 75° C. for about 3 hours and 1-amino-4-methylpiperazine, acidified with acetic acid, added directly according to the procedure described in Example 1, followed by analogous working up to give substantially pure rifampicin.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04174320 |
| 出典データセット | uspto-grants-1979_11 |
| ORD ID | ord-1bae79cdb4cd473f92543be6b20fce4c |
| 出典メモ | uspto-grants-1979_11 |